Translational Research Scientist - II (Associate)

Required Experience and Skills:
• B.S with a minimum of 5+ years’; M.S with 3+ years'; Ph.D. with 1-2 years' of relevant work experience in industry or academia.
• Experience with immunohistochemistry and multiplexed immunofluorescence assay development.
• Experience using digital image analysis software and spatial imaging platforms such as:

HALO
Visiopharm
QuPath
Digital slide scanning
Multiplex spectral imaging
Akoya Polaris
Phenocycler/Fusion
• Strong organizational abilities and communication skills.
Preferred Experience and Skills:
• High level of comfort with histology/microanatomy is strongly preferred.
• Background in oncology and/or immunology.
• Programming skills with application in imaging (e.g., Python, MATLAB).
• Experience with version control environments, such as Git.
• Experience with high-performance Linux clusters and cloud computing.
• Familiarity with client-server and cloud computing infrastructure.

Position Overview:
The Anatomic Pathology group within the Profiling & Expression department is seeking a motivated, experienced scientist with expertise in multiplexed immunofluorescence assay development and digital image analysis to support discovery and translational research in our pathology group in South San Francisco.

Responsibilities:
The successful candidate will:

• Perform validation and quality checks of analysis readouts on multiplexed immunofluorescence images.
• Perform image preprocessing tasks according to established SOPs, including:

Metadata extraction
Output quality control
Secure data transfer to cloud storage
• Assist in evaluating and implementing new algorithms to enhance the image analysis pipeline, including:
Cell segmentation improvements
Tissue classification
Cell phenotyping
• Assist with data transfer and image-related information for analysis, facilitating smooth collaboration between teams.
• Coordinate with IT to:
Gather and document feedback from users on image analysis workflows and tools.
Address user pain points, define requirements, and improve tool functionality.
Lead user experience testing, working with IT to implement improvements and optimize tools for production use.
Maintain and update image analysis computers to ensure they remain optimized for routine tasks.
• Define and document requirements for new tools and ensure their successful deployment.
• Provide administrative support for multiplex IHC-related work, including:
Reagent ordering
Capital equipment purchasing
Documenting and maintaining SOPs for image processing and analysis workflows
• Interact smoothly with scientists, computer scientists, and informatics/IT staff, both internally and externally.