Scientist - III (Senior) - CA Only

Qualifications: This is a Bio-conjugation Scientist role

Education Requirement:

• Minimum qualifications include a B.S./M.S/ PHD in chemistry, biochemistry, or related field, with industrial or academic experience. Experience and Skills Required:

• Hands on experience with conjugation, purification and characterization of antibody drug conjugates, and experience using analytical techniques/instrumentation, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC, SDS-PAGE, UV‐Vis.

• Nice to have skills: Biologics analytic experience, purification techniques.

•Must have: Bio-conjugation experience, protein biochemistry and Chemistry background.

• Personality: Team player, Adheres to timeline, Communicative and collaborative.

This is a Bio-conjugation Scientist role with MRL SSF Discovery Chemistry group.

Merck is currently seeking highly motivated and exceptional a Bio-conjugation Scientist for position within the Discovery Chemistry Department located at our South San Francisco, CA site.

• The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates.

• Successful candidates must have excellent interpersonal, collaboration, and communication skills in a team environment.

• Additionally, it is expected that the successful candidate will learn quickly through on-the-job training to become increasingly skilled and independent in reaction setup, route design and optimization. Specific responsibilities will include:

• Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods

•Selection and application of appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography)

• Acquisition and interpretation of analytical data such as LC/MS.